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Painkillers and Vaccination

Putting aside for one moment any issues surrounding the safety or need for vaccination, many parents do vaccinate their children. Many people choose, and are advised, to take a painkiller before a vaccination to minimise after-effects. New research shows this may be the wrong thing to do. When immune cells were exposed to over-the-counter painkillers paracetamol, aspirin and ibuprofen, their ability to produce antibodies was diluted. This is probably because the pain-killing action of these drugs is due in part to reducing the action of an enzyme called cox-2. This is not a good idea in the context of vaccination, however, because the cox-2 enzyme is necessary for the optimal production of B-lymphocytes, the immune cells that produce antibodies.
Source: Cellular Immunology
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